Kate Grant is the executive director of the Fistula Foundation www.fistulafoundation.org, the largest U.S. based nonprofit focused exclusively on fighting the childbirth injury obstetric fistula globally.
The National Fistula Center, established in 2003, provides surgeries to women who need it free of charge and can then refer them to the rehabilitation center to get re-acclimated to living in their communities once rehabilitated.
Fistula exists in Nepal, but a more common problem seems to be uterine prolapse, which is when the uterus descends through the genitals.
Fistula is just a symptom of a much bigger problem.
The charities to which C.K. is donating over a quarter of his earnings are the Fistula Foundation which helps women, Charity: Water, which provides clean drinking water; Green Chimneys and the Pablove Foundation which help children in need and Kiva, an organization that offers "microfunds" or small loans to people around the world.